Derek Grant tallies the lone goal for Buffalo.
Coming off a 1-0 preseason shootout victory over the Toronto Maple Leafs on Thursday night in St. Catherines, Ontario, the Leafs erupted for 4 goals in the first period on Friday night at the Key Bank Center en route to an 8-1 victory.
Derek Grant scored the only Buffalo goal in the first period, with an assist from Justin Bailey.
Sabres starting goalie Jason Kasdorf, who is anticipated to be one of the Rochester Americans netminders this season, was tagged for the 4 goals on 13 shots.
John Muse, who signed with the Amerks for this season as well, took over in the second period in goal for the Sabres and gave up 4 goals, including one while the Sabres were down 2 men.
Greece native and Sabres captain Brian Gionta had no shots on goal and was a -1.
Toronto outshot Buffalo, 40-23.
RFA Rasmus Ristolainen is practicing with the Sabres despite not yet having signed a contract. The Sabres do have an offer on the table.